Fertility of male or female rats evaluated at dose levels as high as 200 mg kg day or 100 times the maximum recommended human dose was unaffected by atenolol administration. Unlike propranolol or metoprolol, but like nadolol, hydrophilic atenolol undergoes little or no metabolism by the liver, and the absorbed portion is eliminated primarily by renal excretion. Atenolol is also compatible with methyldopa, hydralazine, and acheter tenoretic boutique en ligne prazosin, the combination resulting in larger fall in blood pressure than with the single agents. Any chloride deficit during thiazide therapy is generally mild and usually does not require specific treatment except under extraordinary circumstances as in liver disease or renal disease.